A practical reference on REV-ERB: what it is, how it behaves, what the literature reports, and where the honest uncertainties sit.
This page was last updated on 2025-09-14 and is reviewed periodically as new material appears.
Storage conditions for research-grade SR9009 generally involve a freezer at approximately minus twenty degrees Celsius, sometimes lower for long-term preservation. Containers should remain tightly closed and protected from light. Desiccants may be used to limit moisture uptake. Solutions are often stored in aliquots to avoid repeated warming and cooling. Stability data for the compound under various conditions are limited, so laboratories typically follow supplier recommendations and verify performance through periodic analytical checks rather than assuming indefinite stability.
Identity and purity testing for SR9009 commonly uses liquid chromatography coupled with tandem mass spectrometry. This method separates the compound from matrix components and detects it by mass-to-charge transitions, providing sensitive and specific confirmation. Nuclear magnetic resonance spectroscopy can support structural identification, while high-performance liquid chromatography with ultraviolet detection may estimate purity. Because online products labeled as SR9009 may contain other substances or no active compound at all, independent verification is important in research settings. Certificates of analysis are useful but not a substitute for in-house testing.
SR9009 is frequently discussed alongside other REV-ERB ligands, including synthetic agonists and natural heme-related molecules. Its selectivity for REV-ERB over related nuclear receptors has been measured in binding and reporter assays, though off-target activity at higher concentrations is possible. The compound is prohibited in sport by the World Anti-Doping Agency, and it is not approved for any medical use in major jurisdictions. Products sold online may be labeled as research chemicals, and their identity and purity are not guaranteed by regulatory review.
SR9009 is a synthetic small molecule that acts on the nuclear receptors REV-ERBα and REV-ERBβ. These receptors are part of the circadian clock machinery and normally repress transcription of certain target genes. In laboratory research, SR9009 is used as a chemical tool to study how REV-ERB activity influences metabolism, inflammation, and daily biological rhythms. The compound is not an approved medicine, and its effects in humans remain largely uncharacterized. It is often described as an investigational agent rather than a therapeutic product.
| Property | Value | Notes |
|---|---|---|
| Appearance | White to off-white powder | Typical for research-grade material |
| Solubility | Soluble in DMSO and ethanol; low aqueous solubility | Organic stock solutions are common |
| Typical storage temperature | -20 °C or lower | Protect from light and moisture |
| Common analytical method | LC-MS/MS | Used for detection and confirmation |
| Common synonyms | SR9009; Stenabolic | Stenabolic is an informal name |
Regulatory treatment of SR9009 varies by country and context. It is not approved as a therapeutic drug by agencies such as the United States Food and Drug Administration or the European Medicines Agency. Sports authorities list it as a prohibited substance; the World Anti-Doping Agency classifies it among hormone and metabolic modulators. Legal status for personal possession or sale differs across jurisdictions, and some countries may restrict it under analog or research chemical laws. Buyers who seek verified material often rely on independent laboratory testing because online product labels may not match contents.
Laboratory samples of SR9009 are typically handled as research chemicals rather than pharmaceuticals. Suppliers usually state that the material is for research use only and not for human or veterinary administration. Storage recommendations generally call for a freezer at approximately −20 °C, protection from light, and a desiccated environment. The solid is often described as a white to off-white powder. Solubility is commonly reported in organic solvents such as dimethyl sulfoxide and ethanol, with low solubility in water.
SR9009 stability depends on temperature, moisture, light, and solvent. Solid material is generally kept cool and dry, while solutions may require protection from repeated warming and cooling. Degradation can appear as color changes, precipitate, or new chromatographic peaks. Researchers should follow supplier instructions and their own stability data. Long-term storage conditions for human use have not been established because the compound lacks approved clinical formulation.
SR9009 is supplied as a solid research chemical, often in milligram quantities. Laboratories typically weigh it in a controlled environment because fine powders can disperse. Stock solutions are commonly prepared in dimethyl sulfoxide and stored in small aliquots to reduce freeze-thaw cycles. Personal protective equipment and chemical fume hoods are standard when handling unknown or potent compounds. These practices address laboratory safety rather than human use.
Identity and purity of SR9009 samples are usually checked with chromatographic and spectrometric methods. High-performance liquid chromatography can separate the compound from related impurities, while mass spectrometry provides molecular mass confirmation. Nuclear magnetic resonance spectroscopy may be used for structural verification in research settings. No single method proves biological activity, and certificates of analysis should be reviewed alongside raw data. Independent testing is often needed because online products vary widely.
SR9009 binds REV-ERB receptors and alters their repressive activity on target genes. This action can change transcription of genes involved in lipid handling, glucose metabolism, and mitochondrial function. In rodent studies, treated animals have shown changes in muscle oxidative capacity and exercise performance, though effects vary by dose, duration, and model. The precise molecular steps connecting receptor binding to whole-body outcomes are still an active area of investigation. Findings in animals do not automatically translate to humans.
Because REV-ERB receptors are core clock components, SR9009 has been examined for effects on daily rhythms as well as metabolism. Research has explored whether the compound can shift or reinforce circadian gene expression in tissues such as liver and muscle. Some studies report improved metabolic markers in obese or diabetic mice, while others show context-dependent responses. Questions remain about which effects are direct, which are secondary to timing, and how they might differ across species.
SR9009 is a synthetic small molecule studied as an agonist of REV-ERB nuclear receptors. REV-ERB alpha and REV-ERB beta help regulate circadian rhythms and metabolic gene expression. In laboratory research, SR9009 has been used to probe how these receptors affect skeletal muscle, liver, and adipose tissue. The compound was identified in academic drug-discovery work and is often described in scientific literature by its chemical name and research code. It is not an approved medicine, and human clinical data remain limited or absent.
=== July === 1 July – The ESA space telescope Euclid is launched, beginning a six-year mission to study dark energy and dark matter. 3 July – Researchers demonstrate encoding and storing data – small images – as DNA without new DNA synthesis by recording light exposure into bacterial DNA via optogenetic circuits. The 'biological camera' extends chemical and electrical interface techniques. 5 July Harvard astronomer Avi Loeb reports the possibility of a Galileo project expedition having found first interstellar material. A first evolution experiment of synthetic 'minimal cells' – JCVI-syn3B bacterial cells whose genomes were trimmed to 493 essential genes and are the smallest of any known free-living organism – shows they survive and mutate vitally with their >50% decrease in fitness to JCVI-syn1 being regained after ~2,000 generations under accelerated evolution. 6 July – A study indicates release of methane from Arctic glacial retreat will result in Arctic emissions much higher than expected.
==== United States ==== Phenylethylamine is not a scheduled substance in the United States. However, at least one person in the United States has been prosecuted under the Federal Analogue Act for selling phenylethylamine with the prosecutions argument that PEA is a structural analog of amphetamine and methamphetamine.
=== Municipal administration === The number of inhabitants in Le Havre is between 150,000 and 199,999 so the number of councillors is 59 members. The mayor, 41 aldermen and 17 deputies form the council of Le Havre elected in 2008. It meets on average once a month at the town hall. The debates are generally public except for certain proceedings. Le Havre has experienced many territorial extensions by annexing neighbouring communes:
=== Stress-responsive kinases === Kinases that regulate p53 phosphorylation can be divided into two broad groups. One group includes members of the MAPK pathways, including JNK1–3, ERK1/2 and p38 MAPK, which are activated by diverse cellular stresses such as oxidative stress and heat shock. A second group comprises DNA damage response kinases, including ATM, ATR and DNA-PK, together with downstream checkpoint kinases such as CHK1 and CHK2, which are activated by DNA damage and replication stress and contribute to p53 regulation through phosphorylation-dependent signalling. Additional kinases implicated in p53 phosphorylation include the CDK-activating kinase (CAK; CDK7–cyclin H–MAT1), which has been shown to phosphorylate p53 (for example at Ser33) in vitro and in vivo, and TP53RK (PRPK), which has been reported to phosphorylate p53 at Ser15. Oncogene-induced activation of p53 can also occur via p14ARF (ARF), which inhibits the p53 antagonist MDM2 and thereby stabilizes p53.
==== Unfinished Tales and The History of Middle-earth ==== In 1980, Christopher Tolkien published a collection of more fragmentary material, under the title Unfinished Tales of Númenor and Middle-earth. In subsequent years (1983–1996), he published a large amount of the remaining unpublished materials, together with notes and extensive commentary, in a series of twelve volumes called The History of Middle-earth. They contain unfinished, abandoned, alternative, and outright contradictory accounts, since they were always a work in progress for Tolkien and he only rarely settled on a definitive version for any of the stories. There is not complete consistency between The Lord of the Rings and The Hobbit, the two most closely related works, because Tolkien never fully integrated all their traditions into each other. He commented in 1965, while editing The Hobbit for a third edition, that he would have preferred to rewrite the book completely because of the style of its prose.
Sources: en.wikipedia.org
In Canada, education is a constitutional responsibility of the individual provinces. Provincial governments established the University of Toronto on the Oxbridge model and the University of Alberta and University of Manitoba in the pattern of American state universities. Many older universities in Canada were privately endowed such as McGill University or founded by church denominations, such as Mount Allison University (United Church), Université Laval (Catholic), St Mary's University (Catholic), Queen's University at Kingston (Presbyterian), Dalhousie University (Nonsectarian), St. Francis Xavier University (Catholic), McMaster University (Baptist), and the University of Ottawa (Catholic); these became publicly funded and secular in the 20th century. All major Canadian universities are now publicly funded but maintain institutional autonomy, with the ability to decide admission, tuition, and governance.
The cascade of immune involvement to remove damaged hepatocytes and cholangiocytes ushers regeneration. Yet in infants with biliary atresia regeneration is defective, and results in cirrhosis, as these infants have disrupted p53 and disrupted GSTPi. p53 and GSTPi are responsible for DNA fidelity at regeneration. Hence, these infants get accelerated cirrhosis and advance to portal hypertension.
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The Byzantine-Ottoman wars and the Ottoman wars in Europe brought large numbers of slaves into the Islamic world. To staff its bureaucracy, the Ottoman Empire established a janissary system which seized hundreds of thousands of Christian boys through the devşirme system. They were well cared for but were legally slaves owned by the government and were not allowed to marry. They were never bought or sold. The empire gave them significant administrative and military roles. The system began about 1365; there were 135,000 janissaries in 1826, when the system ended. After the Battle of Lepanto, 12,000 Christian galley slaves were recaptured and freed from the Ottoman fleet. Eastern Europe suffered a series of Tatar invasions, the goal of which was to loot and capture slaves for selling them to Ottomans as jasyr. Seventy-five Crimean Tatar raids were recorded into Poland–Lithuania between 1474 and 1569. Romani people were enslaved in Romania. It was the longest chattel slavery in Europe.
Potatoes were highly valued for their wide diversity and adaptability to different environments and climates. They were commonly used in stews (308). There was also oca (oca), which came in two varieties, sweet and bitter. The sweet variety could be eaten raw or preserved and was used as a sweetener before the arrival of sugar made from sugar cane. Similar to oca in purpose, paiko (Dysphania ambrosioides), was a part of the Inca diet for flavoring and edible leaves. Species of the Chenopodium family in the Inca cuisine were Chenopodium pallidicaule, also known as cañihua, and Chenopodium quinoa, or quinoa, due to their ability to survive in the high altitudes of the Andes. Quinoa has grown popular in the modern world beyond the Andes due to its adaptability, nutritional value, and many uses. Another high-altitude plant in Inca cuisine is Lupinus mutabilis, also known as tarwi or chocho. High in protein, this plant was often eaten with chilis and onions after being carefully treated, since improper treatment can leave the crop poisonous. Like chocho in protein count, Ahipa (Pachyrhizus ahipa) was another crop in Inca cuisine. It grows rapidly and has a high yield rate of the tubers that were cherished for their sweet taste like water chestnuts. Another tuber consumed in the Andes was Tropaeolum tuberosum, also known as mashua and añu in Quechua, due to its resistance to droughts and frost. It was specially prepared and cooked to bring out the flavor that was desired as it was very bitter before doing so.
Sources: en.wikipedia.org
In January 2022, distribution of Lilly's COVID-19 antibody drug was paused due to lack of efficacy against the emerging omicron variant. A second COVID-19 monoclonal antibody therapy, bebtelovimab, developed with AbCellera, was granted Emergency Use Authorization in February 2022, with the U.S. government committing to a $720 million purchase of up to 600,000 doses. In May 2022, the FDA approved Lilly's type 2 diabetes drug Mounjaro (tirzepatide). In August 2022, following the overturning of Roe v. Wade in the Dobbs decision, the state of Indiana passed a near total ban on abortion, and Lilly said the move would make it difficult to attract talent to the state and that it would be forced to look for "more employment growth" elsewhere. In October 2022, Lilly acquired the gene therapy developer Akouos for $487 million in upfront and $123 million deferred payments. In early 2020, Lilly introduced the Lilly Insulin Value Program, where people who have commercial insurance or no insurance can receive a savings card to fill their entire monthly prescription of any Lilly insulin for $35. In 2023, the Inflation Reduction Act extended a similar concept across all insulin suppliers by capping out-of-pocket costs for insulin at $35 per monthly prescription among Medicare Parts B and D enrollees. In January 2023, Lilly and TRexBio announced a collaboration and license agreement for three assets to treat immune-mediated diseases. TRexBio received an upfront payment of $55 million as part of this deal.
Shaanxi Zhongbang Pharma-Tech Co., Ltd.-Supply of Epidermal Growth Factor EGF at the Human Protein Reference Database Archived 2005-05-03 at the Wayback Machine. Epidermal+growth+factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) EGF model in BioModels database
=== Names === Lidocaine is the International Nonproprietary Name (INN), British Approved Name (BAN), and Australian Approved Name (AAN), while lignocaine is the former BAN and AAN. Both the old and new names will be displayed on the product label in Australia until at least 2023. Xylocaine is a brand name, referring to the major synthetic building block 2,6-xylidine. The "ligno" prefix is chosen because "xylo" means wood in Greek while "ligno" means the same in Latin. The "lido" prefix instead refers to the fact that the drug is chemically related to acetanilide.
=== 1964 === January 12: the Arab-dominated government of the Zanzibar Sultanate is overthrown by John Okello, establishing the new people's republic. The new regime orders a massacre against minorities, resulting in the deaths of hundred to thousand Arabs and South Asians in Zanzibar. January 27: France recognizes the People's Republic of China. The Republic of China severs diplomatic relations with France on February 10. March 31–April 1: A military-led coup d'état overthrows president João Goulart in Brazil. Goulart's proposals, such as land reform and bigger control of the state in the economy, were seen as communist. April 20: U.S. President Lyndon Johnson in New York, and Soviet First Secretary Nikita Khrushchev in Moscow, announce simultaneously plans to cut back production of materials for making nuclear weapons. May 27: Jawaharlal Nehru dies. The Colombian conflict begins. July 4: The Rhodesian Bush War begins when African nationalist / Marxist insurgents rebel against colonial rule in Rhodesia (modern-day Zimbabwe). Nyasaland (renamed Malawi upon independence) becomes independent from the UK. August 4: U.S. President Lyndon B. Johnson claims that North Vietnamese naval vessels had fired on two American destroyers in the Gulf of Tonkin. Although there was a first attack, it was later shown that American vessels had entered North Vietnamese territory first, and that the claim of second attack had been unfounded. The Gulf of Tonkin incident leads to the open involvement of the United States in the Vietnam War, after the Gulf of Tonkin Resolution.
Eggshells, snail shells and most seashells are predominantly calcium carbonate and can be used as industrial sources of that chemical. Oyster shells have experienced recognition as a source of dietary calcium since the early 2010s, but also remain a practical industrial source. Dark green vegetables such as broccoli and kale contain dietarily significant amounts of calcium carbonate, but they not practical as an industrial source. Annelids in the family Lumbricidae, earthworms, possess a regionalization of the digestive track called calciferous glands, Kalkdrüsen, or glandes de Morren, that processes calcium and CO2 into calcium carbonate, which is later excreted into the dirt. The function of these glands is unknown but is believed to serve as a CO2 regulation mechanism within the animals' tissues. This process is ecologically significant, stabilizing the pH of acid soils.
Sources: en.wikipedia.org
Research-grade SR9009 is typically stored frozen at about minus twenty degrees Celsius, protected from light and moisture. Stock solutions are often kept in aliquots to avoid repeated freeze-thaw cycles. Specific storage conditions should follow the supplier's documentation.
Liquid chromatography with tandem mass spectrometry is widely used to detect and confirm SR9009 in laboratory samples. The technique offers high sensitivity and can distinguish the target compound from related substances. Nuclear magnetic resonance and ultraviolet detection may support identity and purity checks.
Online products labeled as SR9009 may vary in identity, purity, and actual content. Independent testing helps confirm that a sample matches its label and does not contain unexpected contaminants. This is important for reproducible research and for interpreting experimental results.
SR9009 is a synthetic research compound that binds and modulates the nuclear receptors REV-ERBα and REV-ERBβ. It is used in laboratory studies of circadian biology and metabolism, not as an approved medicine. It is also known by the informal name Stenabolic.